Synthesis of a technetium-99m labelled L-tyrosine derivative with the fac-99mTc(I)(CO)3-core using a simple kit-procedure

✍ Scribed by Ralf Schirrmacher; Slobodan Comagic; Esther Schirrmacher; Frank Rösch

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: French
• Weight: 114 KB
• Volume: 47
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.831

✦ Synopsis

Abstract

The synthesis of a novel technetium‐99m labelled derivative of L‐tyrosine as a potential tumour imaging agent for nuclear medicine diagnosis is reported. The synthesis involved the labelling precursor fac‐[^99m^Tc(OH~2~)(CO)~3~]^+^ which was synthesized using the commercially available Isolink^®^‐labelling kit and the tyrosine derivative O‐(N,N‐bis(carboxymethyl)aminoethyl)‐L‐tyrosine trifluoroacetate. The labelled compound O‐(^99m^Tc(I)‐tricarbonyl‐N,N‐bis(carboxymethyl)aminoethyl)‐L‐tyrosine was obtained in a radiochemical yield of 70–80% within 60 min with a radiochemical purity greater than 98% without any HPLC purification step. Purification was achieved merely by solid phase extraction. Chemical as well as chiral purity was determined using gradient‐ and chiral HPLC. Copyright © 2004 John Wiley & Sons, Ltd.