𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis, labelling and biological characteristics of derivatives of Mercaptoacetyltriglycine with two amide functions

✍ Scribed by S. M. Okarvi; K. Verbeke; P. Adriaens; A. M. Verbruggen

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
188 KB
Volume
45
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Eight novel derivatives of MAG~3~, containing in their structure two instead of three amide functions, have been synthesized and evaluated. The synthesized ligands were labelled with ^99m^Tc by exchange labelling at 100Β°C and/or by a direct labelling method at room temperature. After labelling with ^99m^Tc, the reaction mixtures were analyzed by radio‐HPLC. Biological evaluation of different ^99m^Tc‐diamide complexes in mice and a baboon indicated that substitution in one amide function of MAG~3~ structure greatly influences the renal handling of these compounds. It was found that the diamide derivatives containing at least one inverted amide exhibit biological behavior comparable to that of ^99m^Tc‐MAG~3~. Copyright Β© 2002 John Wiley & Sons, Ltd.

πŸ“œ SIMILAR VOLUMES

Synthesis and biological characteristics
Synthesis and biological characteristics of the Technetium-99m triamide derivatives of mercaptoacetyltriglycine (MAG3)
✍ S. M. Okarvi; P. Adriaens; A. M. Verbruggen πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 French βš– 154 KB

A number of MAG 3 -derivatives, containing the three-amide functions modified by inverting the sequence -CO-NH-to -NH-CO-in the firstand/or second-amide functions, have been labelled with 99m Tc in order to study the renal characteristics of the resulting MAG 3 -derivatives versus the reference 99m

Synthesis, radiolabelling and biological
Synthesis, radiolabelling and biological evaluation of terminal oxamide derivatives of mercaptoacetyltriglycine
✍ S.M. Okarvi; P. Torfs; P. Adriaens; A.M. Verbruggen πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 French βš– 151 KB

99m Tc-MAG 3 is widely used in clinical nuclear medicine as a potential replacement of 131 I-OIH for renal function studies. The terminal carbonylglycine in the MAG 3 backbone is assumed to be essential for maintaining its efficient renal handling characteristics. A number of MAG 3 -derivatives have

Synthesis and evaluation of biological a
Synthesis and evaluation of biological activity of two novel tritium-labeled derivatives of riodipine
✍ V. P. Shevchenko; N. F. Myasoedov; N. M. Soldatov; G. J. Duburs; V. V. Kastron; πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 French βš– 402 KB

Author t o whom c o r r e s p o n d e n c e s h o u l d be a d d r e s s e d . SUHMARY 2,6-Dimethyl-3-met hoxy c a r b o n y l -5-([2,3-3;12] -2-propoxyc a r b o n y l ) -4-( 2' -d i f l u o r o m e t h o x y p h e n y l ) -1 . 4 -d i h y d r o p y r i d i n e and 2.6-dim e t h y l -3 , 5 -d i ( [ 2

Polyaniline with Two Types of Functional
Polyaniline with Two Types of Functional Groups: Preparation and Characteristics
✍ Shaolin Mu πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 354 KB

## Abstract Summary: Polyaniline with two types of functional groups (sulfonated poly(aniline‐__co__‐__o__‐aminophenol), s‐copolymer) has been prepared by the electrochemical copolymerization of aniline and __o__‐aminophenol in sulfuric acid solution followed by sulfonation of the copolymer in the