Synthesis and Pharmacological Activity of Two Derivatives of the Amide of Valproic Acid
β Scribed by Elly Bechar; Henri Astroug
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 323 KB
- Volume
- 330
- Category
- Article
- ISSN
- 0365-6233
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
Propylisopropyl acetamide (PID), an amide analogue of the major antiepileptic drug valproic acid (VPA), possesses favorable anticonvulsant and CNS properties. PID contains one chiral carbon atom and therefore exists in two enantiomeric forms. The purpose of this work was to synthesize the two PID en
## Abstract The pharmacokinetics of the following two polyesteric prodrugs of valproic acid (VPA) have been investigated: 1,4βbutanediol divaiproate (BDV) and glyceryl trivalproate (GTV). In addition, the anticonvulsant activity of these compounds has been evaluated and compared to that of VPA and