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Teratology study of derivatives of tetramethylcyclopropyl amide analogues of valproic acid in mice

✍ Scribed by Akinobu Okada; Yuko Onishi; Yoshinobu Aoki; Boris Yagen; Eyal Sobol; Meir Bialer; Michio Fujiwara

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
127 KB
Volume
77
Category
Article
ISSN
1542-9733

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## Abstract **BACKGROUND:** Although valproic acid (VPA) is used extensively for treating various kinds of epilepsy, it causes hepatotoxicity and teratogenicity. In an attempt to develop a more potent and safer second generation to VPA drug, the amide derivatives of the tetramethylcyclopropyl VPA a

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## Abstract **BACKGROUND:** The antiepileptic drug valproic acid (VPA) is well known to cause neural tube and skeletal defects in both humans and animals. The amidic VPA analogues valpromide (VPD) and valnoctamide (VCD) have much lower teratogenicity than VPA inducing exencephaly in mice. The objec

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## Abstract ## BACKGROUND Valproic acid (VPA) is widely used to treat epilepsy and bipolar disorder and is also a potent teratogen, but its teratogenic mechanisms are unknown. We have attempted to describe a fundamental role of the Polycomb group (Pc‐G) in VPA‐induced transformations of the axial