Anticonvulsant profile and teratogenic evaluation of potent new analogues of a valproic acid urea derivative in NMRI mice

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Tetramethylcyclopropyl analogue of the leading antiepileptic drug, valproic acid: Evaluation of the teratogenic effects of its amide derivatives in NMRI mice

✍ Akinobu Okada; Yuko Onishi; Boris Yagen; Jakob Avi Shimshoni; Dan Kaufmann; Meir 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 328 KB 👁 1 views

## Abstract **BACKGROUND:** Although valproic acid (VPA) is used extensively for treating various kinds of epilepsy, it causes hepatotoxicity and teratogenicity. In an attempt to develop a more potent and safer second generation to VPA drug, the amide derivatives of the tetramethylcyclopropyl VPA a