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Synthesis and biological activity of pyridopyridazin-6-one p38α MAP kinase inhibitors. Part 2

✍ Scribed by Tynebor, Robert M.; Chen, Meng-Hsin; Natarajan, Swaminathan R.; O’Neill, Edward A.; Thompson, James E.; Fitzgerald, Catherine E.; O’Keefe, Stephen J.; Doherty, James B.


Book ID
120380220
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
481 KB
Volume
22
Category
Article
ISSN
0960-894X

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Synthesis and biological activity of pyr
✍ Robert M. Tynebor; Meng-Hsin Chen; Swaminathan R. Natarajan; Edward A. O’Neill; 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 705 KB

The development and synthesis of potent p38α MAP kinase inhibitors containing a pyridazinone platform is described. Evolution of the p38α selective pyridopyridazin-6-one series from the p38α/β dual inhibitor 2H-quinolizin-2-one series will be discussed in full detail.