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Synthesis, Biological Testing, and Binding Mode Prediction of 6,9-Diarylpurin-8-ones as p38 MAP Kinase Inhibitors

✍ Scribed by Hauser, Dominik R. J.; Scior, Thomas; Domeyer, David M.; Kammerer, Bernd; Laufer, Stefan A.


Book ID
115525324
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
334 KB
Volume
50
Category
Article
ISSN
0022-2623

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The development and synthesis of potent p38Ξ± MAP kinase inhibitors containing a pyridazinone platform is described. Evolution of the p38Ξ± selective pyridopyridazin-6-one series from the p38Ξ±/Ξ² dual inhibitor 2H-quinolizin-2-one series will be discussed in full detail.