✦ LIBER ✦

Synthesis and biological activity of pyridopyridazin-6-one p38 MAP kinase inhibitors. Part 1

✍ Scribed by Robert M. Tynebor; Meng-Hsin Chen; Swaminathan R. Natarajan; Edward A. O’Neill; James E. Thompson; Catherine E. Fitzgerald; Stephen J. O’Keefe; James B. Doherty

Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 705 KB
Volume: 21
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.10.128

No coin nor oath required. For personal study only.

✦ Synopsis

The development and synthesis of potent p38α MAP kinase inhibitors containing a pyridazinone platform is described. Evolution of the p38α selective pyridopyridazin-6-one series from the p38α/β dual inhibitor 2H-quinolizin-2-one series will be discussed in full detail.

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