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p38 MAP kinase inhibitors. Part 6: 2-Arylpyridazin-3-ones as templates for inhibitor design

✍ Scribed by Swaminathan R. Natarajan; Stephen T. Heller; Kiyean Nam; Suresh B. Singh; Giovanna Scapin; Sangita Patel; James E. Thompson; Catherine E. Fitzgerald; Stephen J. O’Keefe


Book ID
108074143
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
320 KB
Volume
16
Category
Article
ISSN
0960-894X

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The development and synthesis of potent p38α MAP kinase inhibitors containing a pyridazinone platform is described. Evolution of the p38α selective pyridopyridazin-6-one series from the p38α/β dual inhibitor 2H-quinolizin-2-one series will be discussed in full detail.