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Synthesis and antiviral evaluation of α-l-2′-deoxythreofuranosyl nucleosides

✍ Scribed by Kiran S. Toti; Marco Derudas; Christopher McGuigan; Jan Balzarini; Serge Van Calenbergh

Book ID
113582976
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
504 KB
Volume
46
Category
Article
ISSN
0223-5234

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✍ Kohei Yamada; Hiroyuki Hayakawa; Shinji Sakata; Noriyuki Ashida; Yuichi Yoshimur 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 427 KB

We have identified a selective S(N)2' reaction triggered by iodide ion that leads to the ring-opening of 2,2'-anhydro-α-nucleosides. By applying the method, we have synthesized α-D-2',3'-didehydro-2',3'-dideoxy-3'-C-hydroxymethyl nucleosides, designed as potential antiviral agents.