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Synthesis and Antiviral Evaluation of Novel Cyclopropyl Nucleosides, Phosphonate Nucleosides and Phosphonic Acid Nucleosides

✍ Scribed by Chang Hyun Oh; Joon Hee Hong

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
534 KB
Volume
339
Category
Article
ISSN
0365-6233

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## Abstract Reaction of 6‐chloropyrimidines with diethyl [(2‐aminoethoxy)methyl]phosphonate allows for a ready access to acyclic nucleoside phosphonates. A series of 5‐substituted pyrimidines bearing a phosphonate side chain at position 6 were synthesized and tested against herpes simplex viruses (