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Synthesis of acyclic nucleoside phosphonates as antiviral compounds

✍ Scribed by Frank Wormstädt; Michael Gütschow; Kurt Eger; Ute Brinckmann

Publisher
Journal of Heterocyclic Chemistry
Year
2000
Tongue
English
Weight
426 KB
Volume
37
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

Reaction of 6‐chloropyrimidines with diethyl [(2‐aminoethoxy)methyl]phosphonate allows for a ready access to acyclic nucleoside phosphonates. A series of 5‐substituted pyrimidines bearing a phosphonate side chain at position 6 were synthesized and tested against herpes simplex viruses (HSV‐1 and HSV‐2) and human immunodeficiency virus (HIV‐1). Some compounds showed weak antiviral activity against HSV‐1.

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