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Racemic Synthesis and Antiviral Evaluation of 4′(α)-Hydroxymethyl and 6′(α)-Methyl Substituted Apiosyl Nucleosides.

✍ Scribed by Aihong Kim; Joon Hee Hong

Publisher
John Wiley and Sons
Year
2007
Weight
25 KB
Volume
38
Category
Article
ISSN
0931-7597

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Synthesis and Antiviral Evaluation of Novel 4′-Hydroxymethyl Branched Thioapiosyl Nucleosides
✍ Jin Woo Kim; Joon Hee Hong 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 108 KB 👁 2 views

## Abstract In this study, we synthesized novel 4′‐hydroxymethyl branched thioapiosyl nucleosides. The thioapiosyl sugar moiety was constructed using sequential ozonolysis and reduction. The natural bases (uracil, thymine, cytosine, and adenine) were efficiently coupled using the Vorbrüggen glycosy