Synthesis and antitumor activity of some acyl derivatives of erythro- and threo-DL-phenylserines
โ Scribed by N. Dirvyanskite; I. Straukas; A. Kershulis; Ya. Valavichene
- Book ID
- 111951035
- Publisher
- Springer
- Year
- 1976
- Tongue
- English
- Weight
- 334 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0091-150X
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๐ SIMILAR VOLUMES
A series of N-formyl-O-acyl-ฮฒ-phenylserine derivatives 1b -7b were prepared by the interaction of N-acylฮฒ-phenylserine ethyl esters 1a-7a with formic acid in presence of 1.5% HF. One-pot acyl group NโO migration followed N-formylation under elaborated reaction conditions. Results and Discussion
DL-erythro-sphingosine and DL-threo-sphingosine specifically labelled with 3H in positions 4 and 5 were prepared. The synthesis of these compounds was based on a modification of a procedure published by Grob and Gadient. Quantitative separation of the sphingosines from acetylenic impurities was acco