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Synthesis of dl-erythro and threo-sphingosine-4,5-3H

✍ Scribed by Andrew E. Gal

Publisher: John Wiley and Sons
Year: 1967
Tongue: French
Weight: 420 KB
Volume: 3
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2590030206

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✦ Synopsis

DL-erythro-sphingosine and DL-threo-sphingosine specifically labelled with 3H in positions 4 and 5 were prepared. The synthesis of these compounds was based on a modification of a procedure published by Grob and Gadient. Quantitative separation of the sphingosines from acetylenic impurities was accomplished, and the physical constants of pure DL-erythro and threo sphingosines were determined. D-erythro sphingosine was prepared by resolving the DL racemate and it was found identical to the naturally occurring product.

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