A short enantiodivergent synthesis of d-erythro and l-threo sphingosine
✍ Scribed by Noureddine Khiar; Kamaljit Singh; Mercedes García; Manuel Martín-Lomas
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 248 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
## Isolated vield. \*) The free amine bases 1 4 are prone to air-oxidation and are difficult to handle.
DL-erythro-sphingosine and DL-threo-sphingosine specifically labelled with 3H in positions 4 and 5 were prepared. The synthesis of these compounds was based on a modification of a procedure published by Grob and Gadient. Quantitative separation of the sphingosines from acetylenic impurities was acco
The chiral diazaborolidine 1 has been applied to the enantioselective syntheses of chloramphenicol ( 2) and (D)-threo-N-acetylsphingosine (3), a synthetic precursor of the diastereomeric (D)-sphingosines.