✦ LIBER ✦

Synthesis and Antiplatelet Activity of 1-tert-Butylamino-3-(3-thienyloxy)-2-propanols

✍ Scribed by Susana Abdallah; Victoriano Darias; Rosa Donoso; Pilar Jordán de Urríes; Jaime Lissavetzky

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 600 KB
Volume: 329
Category: Article
ISSN: 0365-6233
DOI: 10.1002/ardp.19963290408

No coin nor oath required. For personal study only.

✦ Synopsis

The synthesis of new l-terf-butylamino-3-(3-thienyloxy)-2propanols by two alternative methods is described. Their initial antiplatelet activity evaluation against ADP, adrenaline, and collagen is reported, and the preliminary structure-activity relationships are established. The appropriateness of further pharmacological investigations, especially for the best compound of the series lf, is indicated.

📜 SIMILAR VOLUMES

β-Adrenoceptor Blocking Activity of 3-Al

β-Adrenoceptor Blocking Activity of 3-Alkylamino-1-(3-benzo[b]thienyloxy)-2-propanols and Closely Related Bicyclic Compounds

✍ Santiago Conde; Carlos Corral; Jaime Lissavetzky; Victoriano Darias; Olga Galván 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 English ⚖ 382 KB

A preliminary pharmacological study of a thiophenic isoster of propranolol and related compounds with a tert. butylamino or homoveratrylamino group instead of the isopropylamino group is described. The synthesis and some pharmacological properties of derivatives in which the benzene ring is replaced

Stereoselective synthesis of the (R)- an

Stereoselective synthesis of the (R)- and (S)-1-(2-amino-3-nitrophenoxy)-3-(tert-butylamino)-2-propanol from the enantiomeric glycidyl tosylates

✍ Akli Hammadi; Christian Crouzel 📂 Article 📅 1990 🏛 Elsevier Science 🌐 English ⚖ 181 KB

Synthesis of 1-Alkoxy-3-N-succinimido-2-

Synthesis of 1-Alkoxy-3-N-succinimido-2-propanols

✍ R. A. Gasanov; M. A. Allakhverdiev 📂 Article 📅 2005 🏛 SP MAIK Nauka/Interperiodica 🌐 English ⚖ 32 KB

GLC determination of S-2-(3-tert-butylam

GLC determination of S-2-(3-tert-butylamino-2-hydroxypropoxy)-3-cyanopyridine in human plasma

✍ S. Vickers; C. A. H. Duncan 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 English ⚖ 231 KB 👁 1 views

S-2-(3-tert-Butylamino-2-hydroxypropoxy)-3-cyanopyridine was recovered (approximately 90%) from human plasma and detected by conversion to a diheptafluorobutyryl derivative for electron-capture GLC. A homolog served as an internal standard. The method measures plasma drug concentrations at the 5-ng/

Ether Derivatives of 3-Amino-1,2-propane

Ether Derivatives of 3-Amino-1,2-propanediols, IV. Syntheses and Pharmacological Investigations of 1-Cycloalkoxy-3-amino-2-propanols and 1-Cycloalkoxy-3-guanidino-2-propanols

✍ Elena Chalina; Damian Dantchev; Atanas Georgiev; Duschka Staneva 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 327 KB 👁 2 views

ChemInform Abstract: Microwave-Promoted

ChemInform Abstract: Microwave-Promoted Synthesis of 1-Aryloxy-3-alkylamino-2-propanols.

✍ B. PCHELKA; J. PLENKIEWICZ 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 1 views

## Microwave-Promoted Synthesis of 1-Aryloxy-3-alkylamino-2propanols. -Microwave heating is found to accelerate significantly both steps of the known synthesis of the title compounds (V) from epichlorohydrin. -(PCHELKA, B.;