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GLC determination of S-2-(3-tert-butylamino-2-hydroxypropoxy)-3-cyanopyridine in human plasma

โœ Scribed by S. Vickers; C. A. H. Duncan

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
231 KB
Volume
68
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

S-2-(3-tert-Butylamino-2-hydroxypropoxy)-3-cyanopyridine was recovered (approximately 90%) from human plasma and detected by conversion to a diheptafluorobutyryl derivative for electron-capture GLC. A homolog served as an internal standard. The method measures plasma drug concentrations at the 5-ng/ml level and is suitable for plasma analysis from humans who receive a therapeutic oral dose.

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