## Abstract Pentadeuteriophenyl clobazam 5 was synthesized in essentially quantitative isotopic purity, and characterized by ^1^HβNMR and mass spectroscopy. The title compound was found to be β₯98% pure by HPLC, and its retention time (t~R~ 6.17 min) was less than that of an authentic clobazam stand
GLC determination of 7-trifluoromethyl-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione in plasma
β Scribed by Leonard C. Bailey; Arvin P. Shroff
- Publisher
- John Wiley and Sons
- Year
- 1973
- Tongue
- English
- Weight
- 287 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0022-3549
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## Abstract The synthesis from carbonβ^14^C dioxide of 1, 3βdihydroβ1βmethylβ7βnitroβ5βphenylβ2Hβ1, 4βbenzodiazepinβ2βoneβ5β^14^C (I) for use in metabolic studies has been described. The synthesis was achieved by the sequence shown in figure 1. The overall yield of labelled nimetazepam (I) was near