✦ LIBER ✦

β-Adrenoceptor Blocking Activity of 3-Alkylamino-1-(3-benzo[b]thienyloxy)-2-propanols and Closely Related Bicyclic Compounds

✍ Scribed by Santiago Conde; Carlos Corral; Jaime Lissavetzky; Victoriano Darias; Olga Galván

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 382 KB
Volume: 316
Category: Article
ISSN: 0365-6233
DOI: 10.1002/ardp.19833160612

No coin nor oath required. For personal study only.

✦ Synopsis

A preliminary pharmacological study of a thiophenic isoster of propranolol and related compounds with a tert. butylamino or homoveratrylamino group instead of the isopropylamino group is described. The synthesis and some pharmacological properties of derivatives in which the benzene ring is replaced by a cyclopentene or cyclohexene ring are also reported. Compoundscaqing the tert. butylamino moiety turned out to be similar to propranolol in their pharmacological properties.

fl-Blockerwirknng von 3--AILylmino-l-(3-~~enzo[b]tbienyloxy)~2-p~~0~ und verwandten bizykliscben Verbindoagen

Eine vorlaufige pharmakologische hiifung von einem Thiophen-isoster des Propranolols und verwandten Derivaten mit einer tert.

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