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Synthesis and antihypertensive activity evaluation in spontaneously hypertensive rats of lacidipine analogues

โœ Scribed by Zeng-jun Guo, Kai Zhou, Yong-xiao Cao, Yan Li, San-qi Zhang


Book ID
113015135
Publisher
Springer-Verlag
Year
2011
Tongue
English
Weight
250 KB
Volume
21
Category
Article
ISSN
1054-2523

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This study of spontaneously hypertensive (SH) rats documents oral antihypertensive activity of the vasodilator Ofornine@, an anthranilamide whose effect was sustained, at least in part, by suppression of compensatory renal and neurohumoral responses. Doses of 2.5 to 100 mg/kg p.0. reduced systolic b