Antihypertensive, vasodilating, and symp
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Albert Defelice; Harlan Lape; Patrick Horan; Richard Frering; Armand Brousseau;
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Article
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1990
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John Wiley and Sons
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English
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This study of spontaneously hypertensive (SH) rats documents oral antihypertensive activity of the vasodilator Ofornine@, an anthranilamide whose effect was sustained, at least in part, by suppression of compensatory renal and neurohumoral responses. Doses of 2.5 to 100 mg/kg p.0. reduced systolic b