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Antihypertensive and hormonal activity of MK 954 in spontaneously hypertensive rats

โœ Scribed by Kenji Mizuno; Susumu Niimura; Makio Tani; Hiroshi Haga; Taihei Gomibuchi; Hironobu Sanada; Soitsu Fukuchi

Book ID
117980202
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
305 KB
Volume
215
Category
Article
ISSN
0014-2999

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Antihypertensive, vasodilating, and symp
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โœ Albert Defelice; Harlan Lape; Patrick Horan; Richard Frering; Armand Brousseau; ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 833 KB

This study of spontaneously hypertensive (SH) rats documents oral antihypertensive activity of the vasodilator Ofornine@, an anthranilamide whose effect was sustained, at least in part, by suppression of compensatory renal and neurohumoral responses. Doses of 2.5 to 100 mg/kg p.0. reduced systolic b