Synthesis and antifungal activity of 3-aryl-6,7-dihydro-5h-pyrrolo[1,2-a]imidazoles
β Scribed by A. M. Demchenko; V. G. Sinchenko; N. G. Prodanchuk; V. A. Kovtunenko; V. K. Patratii; A. K. Tyltin; F. S. Babichev
- Book ID
- 112488110
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 198 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0091-150X
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Several 6, pyrrolo[1,2-a]imidazoles were activated toward functionalization at C-7 by conversion to quaternary imidazolium salts. The MEMCl derived quaternary salts upon treatment with base reacted with both aldehydes and alkyl halides. The MEM group was removed under mild conditions by heating the
1,3-Dihydro-2H-indol-2-ones (oxindoles) and 1,3-dihydro-2H-pyrrolopyridin-2-ones (azaoxindoles) are useful scaffolds that have been explored for various pharmaceutical uses. Herein we report the synthesis of 2-chloro-5,7-dihydro-6H-pyrrolo [2,3d]pyrimidin-6-one (5) and its derivatives, and the appli