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Heterocycles. 10. A facile synthesis of 7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole

✍ Scribed by Philip M. Weintraub; Paul L. Tiernan; John C. Huffman


Book ID
112128559
Publisher
Journal of Heterocyclic Chemistry
Year
1987
Tongue
English
Weight
163 KB
Volume
24
Category
Article
ISSN
0022-152X

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C-7 functionalization of 6,7-dihydro[5H]
✍ Timothy F. Gallagher; Jerry L. Adams πŸ“‚ Article πŸ“… 1989 πŸ› Elsevier Science 🌐 French βš– 286 KB

Several 6, pyrrolo[1,2-a]imidazoles were activated toward functionalization at C-7 by conversion to quaternary imidazolium salts. The MEMCl derived quaternary salts upon treatment with base reacted with both aldehydes and alkyl halides. The MEM group was removed under mild conditions by heating the