Synthesis and antibacterial activity of an immediate precursor of gramicidin S
β Scribed by Satoru Makisumi; Nobuo Izumiya
- Book ID
- 103401799
- Publisher
- Elsevier Science
- Year
- 1970
- Tongue
- French
- Weight
- 194 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
## Abstract The cyclic cationic antimicrobial peptide gramicidinβ S (GS) is an effective topical antibacterial agent that is toxic for human red blood cells (hemolysis). Herein, we present a series of amphiphilic derivatives of GS with either two or four positive charges and characteristics ranging
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
In order to clarify the relationship between antimicrobial activity and peptide-structure, gramicidin S analogs and cationic a-helical model peptides were designed and synthesized. Introduction of cationic side chains in hydrophilic side of gramicidin S increased antimicrobial activity against Gram-