Syntheses of antibacterial peptides, gramicidin S analogs and designed amphiphilic oligopeptides

✍ Scribed by Haruhiko Aoyagi; Shoji Ando; Sannamu Lee; Nobuo Izumiya

• Publisher: Elsevier Science
• Year: 1988
• Tongue: French
• Weight: 666 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(01)86123-8

✦ Synopsis

In order to clarify the relationship between antimicrobial activity and peptide-structure, gramicidin S analogs and cationic a-helical model peptides were designed and synthesized. Introduction of cationic side chains in hydrophilic side of gramicidin S increased antimicrobial activity against Gram-negative bacteria. Amphiphilic structures of the a-helical peptides were found to be effective to show antimicrobial activities against Grampositive bacteria. Increase in number of cationic amino acid residues in the a-helical peptides caused appreciable antlmicrobial activities against Gram-negative bacteria, however, induced lower activities against Gram-positive