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Optical rotatory dispersion and antibacterial activity of the macro-ring analogues of gramicidin S

✍ Scribed by S. Matsuura; N. Izumiya

Book ID
112659574
Publisher
Springer
Year
1972
Tongue
English
Weight
240 KB
Volume
28
Category
Article
ISSN
1420-682X

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## Abstract Gramicidin S (GS) is a cyclo‐decapeptide antibiotic isolated from __Bacillus brevis__. The structural studies have shown that GS forms a two‐stranded antiparallel β‐sheet imposed by two II′ β‐turns. Despite its wide Gram+ and Gram− antimicrobial spectrum, GS is useless in therapy becaus