Monoor dibromo derivatives 2 and 3 were prepared by an efficient two-step route from 10-methyl-azepino [3,4-b]indole-1,5dione 1. Elimination reaction on 2 gave access to 4-bromo-10-methyl-2H,10H-azepino[3,4-b]indole-1,5-diones 4. Finally, 4-substituted 10methyl-2H,10H-azepino [3,4-b]indole-1,5-dione
Synthesis and anti HSV-1 evaluation of novel indole-3,4-diones
✍ Scribed by Scala, Angela ;Cordaro, Massimiliano ;Mazzaglia, Antonino ;Risitano, Francesco ;Venuti, Assunta ;Sciortino, Maria Teresa ;Grassi, Giovanni
- Book ID
- 121195613
- Publisher
- The Royal Society of Chemistry
- Year
- 2011
- Tongue
- English
- Weight
- 214 KB
- Volume
- 2
- Category
- Article
- ISSN
- 2040-2503
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📜 SIMILAR VOLUMES
## Abstract Cyclic β‐amino esters **4**, obtained from lactams, were condensed with indole‐2‐carbonyl chloride to afford the corresponding amides. Similarly, unusual conditions led to cyclisation at the 3‐position of the indole moiety in the presence of __p__TSA and ethylene glycol to afford previo
## Abstract magnified image 1,5‐Disubstituted pyrimidine‐2,4‐diones were synthesized by fusion of 5‐bromouracil with an aniline derivative followed by coupling with benzyl halide whereas the opposite synthesis sequence failed. Also 4,6‐dichloro‐__N,N__,5‐trimethylpyrimidin‐2‐amine was treated with