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Synthesis and anti-HIV-1 evaluation of 1,5-disubstituted pyrimidine-2,4-diones

โœ Scribed by Yasser M. Loksha; Daniel Globisch; Erik B. Pedersen; Paolo La Colla; Gabriella Collu; Roberta Loddo

Publisher
Journal of Heterocyclic Chemistry
Year
2008
Tongue
English
Weight
379 KB
Volume
45
Category
Article
ISSN
0022-152X

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โœฆ Synopsis

Abstract

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1,5โ€Disubstituted pyrimidineโ€2,4โ€diones were synthesized by fusion of 5โ€bromouracil with an aniline derivative followed by coupling with benzyl halide whereas the opposite synthesis sequence failed. Also 4,6โ€dichloroโ€N,N,5โ€trimethylpyrimidinโ€2โ€amine was treated with phenols. The products were tested for their activity against HIVโ€1.

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