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Syntheses of the syn and anti α-amino-β-hydroxy acids of vancomycin: (2S, 3R) and (2R, 3R) p-chloro-3-hydroxytyrosines

✍ Scribed by Anne Girard; Christine Greck; Didier Ferroud; Jean Pierre Genêt


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
263 KB
Volume
37
Category
Article
ISSN
0040-4039

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Baker's Yeast Mediated Enantiospecific Synthesis of anti-(2R,3R)p-Chloro-3-hydroxytyrosine: An α-Amino-β-hydroxy Acid of Vancomycin. -The synthesis of the protected derivative (V) is achieved via baker's yeast-mediated reduction of the α-azido-β-keto ester (II) at pH 4.0. At pH 7.0 the enantioselect