## Abstract Structural information about the products formed when 7,12‐dimethylbenz(__a__)anthracene (DMBA) is bound to DNA in mammalian cell cultures has been sought through studies of the photosensitivities of these products and of various model compounds. Under conditions of light exposure in wh
Syntheses of putative metabolites of 1,2,3,4-tetrahydro-7,12-dimethylbenz[a]anthracene
✍ Scribed by Srivastava, Santosh K. ;Sharma, Pradeep K.
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 427 KB
- Volume
- 1995
- Category
- Article
- ISSN
- 0947-3440
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✦ Synopsis
Abstract
Syntheses of (8α,9α,10α,11β)‐trans‐1,2,3,4,8,9,10,11‐octahydro‐7,12‐dimethyl‐8,9‐epoxybenz[a]anthracene‐10,11‐diol (3) and (8α,9α,10β,11α)‐trans‐1,2,3,4,8,9,10,11‐octahydro‐7,12‐dimethyl‐8,9‐epoxybenz[a]anthracene‐10,11‐diol (4), the putative D‐ring metabolites of 1,2,3,4‐tetrahydro‐7,12‐dimethyl‐benz[a]anthracene (1), starting from 1,2,3,4‐tetrahydro‐10‐methoxy‐7,12‐dimethylbenz[a]anthracene (11), are reported.
📜 SIMILAR VOLUMES
## Abstract One of the most potent carcinogens is 7,12‐dimethylbenz(a)anthracene (7,12‐DMBA), which is used routinely to conduct studies to evaluate carcinogen inhibitors. Its pharmacokinetics have not been reported in the literature. In view of its significant effects on drug metabolizing enzymes
## Abstract The 2 + 4 cycloaddition reaction of 1,4‐naphthoquinone and substituted styrenes was used to prepare 1‐, 2‐, 3‐, and 4‐bromobenz[a]anthracene‐7,12‐diones (BADs). The corresponding bromobenz[a]anthracenes (BAs) were prepared by aluminum tricyclohexoxide reduction of the diones. Lithiation
## Abstract Female Sprague‐Dawley rats were given a subcutaneous injection of the parent hydrocarbon or its K‐region epoxide in 0.1 ml sesame oil on alternate days to a total of 30 doses and observed for sarcoma at the site of injection for 275 days. The parent compounds, benzo(a)__pyrene (0.2 μmol
Methanolysis of the K-region epoxide of 7,12-dimethylbenz (a) anthracene (DMBA) gave rise to two hydroxy-methoxy derivatives which were dehydrated to S-methoxy-DMBA and 6-methoxy-DMBA at a ratio of 5: 1. The data indicate that methanol attacks preferentially at the 5-position of the arene oxide. The