## Abstract One of the most potent carcinogens is 7,12‐dimethylbenz(a)anthracene (7,12‐DMBA), which is used routinely to conduct studies to evaluate carcinogen inhibitors. Its pharmacokinetics have not been reported in the literature. In view of its significant effects on drug metabolizing enzymes
The metabolism of 7,12-dimethylbenz(A)anthracene in cell cultures
✍ Scribed by Leila Diamond; Christian Sardet; George H. Rothblat
- Publisher
- John Wiley and Sons
- Year
- 1968
- Tongue
- French
- Weight
- 776 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0020-7136
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7,12-Dimethylbenz[a]anthracene (DMBA), a potent carcinogen, requires metabolic activation by cytochrome P450s (P450s) t o electrophilic metabolites that result in DNA modification, mutagenicity, and carcinogenicity. In this study, we used eight human forms, four rodent forms, and one rabbit form of