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Syntheses of 4- and 6-substituted thiazolo[4,5-c]pyridines

✍ Scribed by Yuhua Huang; Frank Bennett; Vinay Girijavallabhan; Carmen Alvarez; Tze-Ming Chan; Rebecca Osterman; Mary Senior; Cecil Kwong; Namita Bansal; F. George Njoroge; Malcolm MacCoss

Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
543 KB
Volume
51
Category
Article
ISSN
0040-4039

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✦ Synopsis

A general synthetic approach to 4,6-substituted thiazole[4,5-c]pyridines, involving a novel one-pot thiol deprotection-cyclization key step, is described.

πŸ“œ SIMILAR VOLUMES

Novel methods to functionalize thiazolo[
Novel methods to functionalize thiazolo[4,5-c]pyridines
✍ Vinay Girijavallabhan; Ashok Arasappan; Frank Bennett; Yuhua Huang; F. George Nj πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 French βš– 686 KB

Novel substituted thiazole[4,5-c]pyridines have been synthesized in good yields from unsubstituted thiazole[4,5-c]pyridine using direct C-H coupling reactions and N-oxide rearrangement chemistry.

Syntheses of oxazolo[4,5-c]pyridine and
Syntheses of oxazolo[4,5-c]pyridine and 6-azaindole
✍ Freddy Tjosaas; Ivar Broendbo Kjerstad; Anne Fiksdahl πŸ“‚ Article πŸ“… 2008 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 373 KB

## Abstract magnified image The preparation of oxazolo[4,5‐__c__]pyridine and 6‐azaindole from 4‐bromo‐3‐pivaloylaminopyridine (**8**) is reported. The oxazolopyridine 2‐__tert__‐butyl‐oxazolo[4,5‐__c__]pyridine (**9**) was successfully prepared from **8** in 78% yield by a new base/TBAB promoted

A single-step preparation of thiazolo[5,
A single-step preparation of thiazolo[5,4-b]pyridine- and thiazolo[5,4-c]pyridine derivatives from chloronitropyridines and thioamides, or thioureas
✍ Kiran P. Sahasrabudhe; M. Angels Estiarte; Darlene Tan; Sheila Zipfel; Matthew C πŸ“‚ Article πŸ“… 2009 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 109 KB

## Abstract magnified image A one‐step synthesis of thiazolo[5,4‐__b__]pyridines from an appropriately substituted chloronitropyridine and thioamide, or thiourea, is presented. In particular, the reaction was used to prepare a large number of 6‐nitrothiazolo[5,4‐__b__]pyridine derivatives, bearing

Regioselective metalation of thiazolo[5,
Regioselective metalation of thiazolo[5,4-b]pyridines
✍ Axel Couture; Eric Huguerre; Pierre Grandclaudon πŸ“‚ Article πŸ“… 1989 πŸ› Elsevier Science 🌐 French βš– 131 KB

Lithiation with LDA of thiazolo[5,4-blpyridines occurs regioselectively on the position in the pyridine ring.