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A single-step preparation of thiazolo[5,4-b]pyridine- and thiazolo[5,4-c]pyridine derivatives from chloronitropyridines and thioamides, or thioureas

✍ Scribed by Kiran P. Sahasrabudhe; M. Angels Estiarte; Darlene Tan; Sheila Zipfel; Matthew Cox; Donogh J. R. O'Mahony; William T. Edwards; Matthew A. J. Duncton

Publisher
Journal of Heterocyclic Chemistry
Year
2009
Tongue
English
Weight
109 KB
Volume
46
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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A one‐step synthesis of thiazolo[5,4‐b]pyridines from an appropriately substituted chloronitropyridine and thioamide, or thiourea, is presented. In particular, the reaction was used to prepare a large number of 6‐nitrothiazolo[5,4‐b]pyridine derivatives, bearing hydrogen, alkyl, substituted alkyl, cycloalkyl, aryl, heteroaryl, and amine substituents at the 2‐position. The reaction could also be extended to produce a thiazolo[4,5‐c]pyridine derivative and thiazolo[5,4‐b]pyridines with alternative substituents on the pyridinoid ring. J. Heterocyclic Chem., (2009).

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