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New one- pot synthesis of pyrazolo[3,4-c]pyridazine and isoxazolo-[5,4-b]pyridine derivatives from potassium cyanoacetahydroxamate

✍ Scribed by Eman A. El-Rady; Magda A. Barsy

Publisher: Journal of Heterocyclic Chemistry
Year: 2008
Tongue: English
Weight: 340 KB
Volume: 45
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570450450

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✦ Synopsis

Abstract

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The reaction of potassium cyanoacetohydroxamate 1 with ethyl 2‐aryl‐hydrazono‐3‐oxobutyrates 2 gave the unexpected pyrazolo[3,4‐c]pyridazines 7 and isoxazolo[5,4‐b]pyridines 10 via a one‐pot reaction. A mechanistic proof is suggested to account for the products.

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