One pot syntheses of thiazol-2-hydrazone, pyridino[2,3-d]pyridazine, pyrazolo[3,4-d]pyridazine, and isoxazolo[4,5-d]pyridazine derivatives
โ Scribed by Rafat M. Mohareb; Daisy H. Fleita
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 140 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1042-7163
- DOI
- 10.1002/hc.10026
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โฆ Synopsis
Abstract
Reactions of the pyridazine derivatives 1aโc with phenyl isothiocyanate followed by heterocyclization with ethyl chloroacetate gave the thiazolidinone derivatives 6aโc. The reactivity of 6a towards some chemical reagents was studied. ยฉ 2002 Wiley Periodicals, Inc. Heteroatom Chem 13:258โ262, 2002; Published online in Wiley Interscience (www.interscience.wiley.com). DOI 10.1002/hc.10026
๐ SIMILAR VOLUMES
The latter compound reacts regioselectively with some nitrilimines and nitrile oxides to afford the corresponding pyrazole and isoxazole derivatives, respectively. These reaction products react with hydrazine hydrate to give the novel pyrazolo [3,4-d]pyridazine and isoxazolo [3,4-d]pyridazine deriva
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