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Regioselective synthesis of some novel pyrazoles, isoxazoles, pyrazolo[3,4-d]pyridazines and isoxazolo[3,4-d]pyridazines pendant to benzimidazole

✍ Scribed by Mohamed R. Shaaban; Ahmad M. Farag; Tamer S. Saleh; Fayez H. Osman

Publisher: Journal of Heterocyclic Chemistry
Year: 2007
Tongue: English
Weight: 383 KB
Volume: 44
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570440127

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✦ Synopsis

The latter compound reacts regioselectively with some nitrilimines and nitrile oxides to afford the corresponding pyrazole and isoxazole derivatives, respectively. These reaction products react with hydrazine hydrate to give the novel pyrazolo [3,4-d]pyridazine and isoxazolo [3,4-d]pyridazine derivatives, respectively.

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