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Novel methods to functionalize thiazolo[4,5-c]pyridines

✍ Scribed by Vinay Girijavallabhan; Ashok Arasappan; Frank Bennett; Yuhua Huang; F. George Njoroge; Malcolm MacCoss

Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
686 KB
Volume
51
Category
Article
ISSN
0040-4039

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✦ Synopsis

Novel substituted thiazole[4,5-c]pyridines have been synthesized in good yields from unsubstituted thiazole[4,5-c]pyridine using direct C-H coupling reactions and N-oxide rearrangement chemistry.

πŸ“œ SIMILAR VOLUMES

Syntheses of 4- and 6-substituted thiazo
Syntheses of 4- and 6-substituted thiazolo[4,5-c]pyridines
✍ Yuhua Huang; Frank Bennett; Vinay Girijavallabhan; Carmen Alvarez; Tze-Ming Chan πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 French βš– 543 KB

A general synthetic approach to 4,6-substituted thiazole[4,5-c]pyridines, involving a novel one-pot thiol deprotection-cyclization key step, is described.

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A single-step preparation of thiazolo[5,4-b]pyridine- and thiazolo[5,4-c]pyridine derivatives from chloronitropyridines and thioamides, or thioureas
✍ Kiran P. Sahasrabudhe; M. Angels Estiarte; Darlene Tan; Sheila Zipfel; Matthew C πŸ“‚ Article πŸ“… 2009 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 109 KB

## Abstract magnified image A one‐step synthesis of thiazolo[5,4‐__b__]pyridines from an appropriately substituted chloronitropyridine and thioamide, or thiourea, is presented. In particular, the reaction was used to prepare a large number of 6‐nitrothiazolo[5,4‐__b__]pyridine derivatives, bearing