The phospholipids, ALP and Thio-ALP, are non-hydrolyzable analogues of platelet activating factor (PAF). Interest i n ALP and thio-ALP centers upon their activity as potential antineoplastic agents. A variety of mechanisms of action have been attributed to these compounds including inhibiti$q of a
Syntheses of 2H- and 13C-labeled 1,2-di-O-hexadecyl-sn-glycero-3-phosphoethanolamines and 1,2-di-O-hexadecyl-sn-glycero-3-phosphocholines
✍ Scribed by Osama H. Abdelmageed; Richard I. Duclos Jr.; Robert G. Griffin; David J. Siminovitch; Martin J. Ruocco; Alexandros Makriyannis
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 478 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0009-3084
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## Abstract The syntheses of N‐substituted 1‐O‐alkyl‐2‐desoxy‐2‐amino‐__sn__‐glycero‐3‐[^32^P]phosphocholines were performed in four steps starting from [^32^P] POCl~3~ and the corresponding 1‐O‐alkyl‐2‐amino‐propane‐3‐ols in 5‐7% total yield.
1 -0-[hexadecyl-1',2'-3H]Hexadecyl 2-acetyl-sn-glyceryl3-phosphorylcholine (GPC) was prepared by acetylation of 1-0-alkenyl lysophosphatidylcholine, reduction of the alkenyl lipid with tritium gas over palladium oxide, and separation of molecular species of 1-0-[3H]alkyl2-acetyl GPC by reverse phase
## Abstract Two mixed‐acid lecithins: 1‐stearoyl‐2‐linoleyl‐__sn__‐glycero‐3‐phosphorylcholine (SLL) and 1‐stearoyl‐2‐arachidonoyl‐__sn__‐glycero‐3‐phosphorylcholine (SAL) have been synthesized by phospholipase A~2~ digestion of 1,2‐distearoyl‐__sn__‐glycero‐3‐phosphorylcholine (DSL), followed by r