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Synthesis of [32P]labelled 1-O-alkyl-2-desoxy-2-amino-sn′-glycero-3-phosphocholines

✍ Scribed by H. P. Deigner; B. Fyrnys


Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
195 KB
Volume
34
Category
Article
ISSN
0022-2135

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✦ Synopsis


Abstract

The syntheses of N‐substituted 1‐O‐alkyl‐2‐desoxy‐2‐amino‐sn‐glycero‐3‐[^32^P]phosphocholines were performed in four steps starting from [^32^P] POCl~3~ and the corresponding 1‐O‐alkyl‐2‐amino‐propane‐3‐ols in 5‐7% total yield.


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✍ Un Hoi Do; Yang Hong; Peter Tam; Puliyur Srinivasan 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 480 KB

1 -0-[hexadecyl-1',2'-3H]Hexadecyl 2-acetyl-sn-glyceryl3-phosphorylcholine (GPC) was prepared by acetylation of 1-0-alkenyl lysophosphatidylcholine, reduction of the alkenyl lipid with tritium gas over palladium oxide, and separation of molecular species of 1-0-[3H]alkyl2-acetyl GPC by reverse phase