✦ LIBER ✦

Tritium Labelled 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ALP) and 1-S-Hexadecyl-2-O-ethyl-rac-thioglycero-3-phosphocholine (Thio-ALP)

✍ Scribed by Steven D. Wyrick; Jefferson R. Surles; Susan Morris-Natschke; Claude Piantadosi; Edward J. Modest

Publisher: John Wiley and Sons
Year: 1989
Tongue: French
Weight: 288 KB
Volume: 27
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580270305

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✦ Synopsis

The phospholipids, ALP and Thio-ALP, are non-hydrolyzable analogues of platelet activating factor (PAF).

Interest i n ALP and thio-ALP centers upon their activity as potential antineoplastic agents. A variety of mechanisms of action have been attributed to these compounds including inhibiti$q of a phospholipid cofactor of a phospholipid sensitive Ca -dependent protein kinase. Thio-ALP is at least as active as a growth inhibitor of the HL-60 promyelocytic leukemic cell line as is ALP-the most active reference analogue reported in the literature and is approximately twice as active against the BG-1 and BG-3 human ovarian carcinoma cell lines. To aid in further biochemical studies, we report the synthesis of high specific activity tritium labelled ALP and thio-ALP. These products were obtained by palladium catalyzed reduction of 1-0-octadecenyl and 1-S-hexadecenyl precursors with carrier-free tritium gas.

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