Synthesis of rac-1-(9-o-carboranyl)nonyl-2-methyl-glycero-3-phosphocholine (B-Et-11-OMe), a potential boron carrier for Boron Neutron Capture Therapy (BNCT)

✍ Scribed by Peter Lemmen; Birgit Werner

• Publisher: Elsevier Science
• Year: 1992
• Tongue: English
• Weight: 469 KB
• Volume: 62
• Category: Article
• ISSN: 0009-3084
• DOI: 10.1016/0009-3084(92)90096-8

✦ Synopsis

Boron-containing analogues of ether lipids are proposed as boron carriers in the boron neutron capture therapy (BNCT). The syn-the~ of rac-I-(9-o-Carboranyl)nonyl-2-methyl-glycero-3-phosphocholine (B-Et-I l-OMe) as a in'st representative is described. The carborane is introduced into the readily assembled glycerol ether moiety. The phosphocholine headgroup is introduced by 2-chloro-3methyl-l,3,2-~3-oxazaphmpholane using a phmphoamidite strategy and subsequent ring opening under alkylating conditions.