A synthesis of 3-cyano-4-methyl-5 ( 14 C)-methyl-2-(5-14C)pyrrolyloxamic acid is described. The compound, having specific activity of 66.7 pCi/mmole, was obtained in 19.68% overall yield from uniformly labelled 14C-l-alanine. 14 14 Key Words: 3-Cyano-4-methyl-5( C)-methyl-2-(5-C)pyrrolyloxamic acid,
Syntheses of 2-([14C]methyl)furan and 4-oxo[5-14C]-2-pentenal
✍ Scribed by Vijayalakshmi Ravindranath; Leo T. Burka; Michael R. Boyd
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- French
- Weight
- 246 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
A simple one‐step syntheses of 2‐([^14^C]‐methyl) furan and 4‐oxo‐[5‐^14^C]‐2‐pentenal have been described. Carbon‐14 labeled 2‐methylfuran was synthesized by treatment of 2‐furyl lithium with ^14^C‐methyl iodide, and ^14^C‐acetylacrolein was obtained by peracid oxidation of labeled 2‐methylfuran.
📜 SIMILAR VOLUMES
6-14C]Nitrendipine synthesis started from barium[14]carbonate, which was converted to [ 1-14C] acetyl chloride. The acid chloride was condensed with Meldrum's acid (2,2-dimethyl-1,3-dioxane-4,6-dione). The resulting intermediate was treated with boiling methanol to give methyl [ 3-14C]acetoacetate.
## Abstract 1‐O‐ and 5‐O‐Methyl‐^14^C‐myo‐inositols (methyf‐^14^C‐bornesitol and ‐sequoyitol) were synthesized by methylation of appropriately blocked myo‐inositol derivatives with methyl = ^14^C iodide and potassium hydroxide. The benzyl blocking groups of 1‐O‐methyl‐^14^C‐3,4,5, 6‐tetra‐O‐benzyl‐
## Abstract The syntheses of 4‐amino‐3,2′‐dimethyl‐biphenyl‐3‐methyl‐^14^C, a potent carcinogen and mutagen, and 4‐amino‐2′‐methylbiphenyl‐2′‐methyl‐^14^C, an analogue having weaker activity, are described. In both cases, label was introduced with Cu^14^ CN.