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Syntheses of 1-O-methyl-14C-DL-myo-inositol (methyl-14C-bornesitol) and 5-O-methyl-14C-myo-inositol (methyl-14C-sequoyitol)

✍ Scribed by R. H. Shah; F. Loewus

Publisher
John Wiley and Sons
Year
1970
Tongue
French
Weight
367 KB
Volume
6
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

1‐O‐ and 5‐O‐Methyl‐^14^C‐myo‐inositols (methyf‐^14^C‐bornesitol and ‐sequoyitol) were synthesized by methylation of appropriately blocked myo‐inositol derivatives with methyl = ^14^C iodide and potassium hydroxide. The benzyl blocking groups of 1‐O‐methyl‐^14^C‐3,4,5, 6‐tetra‐O‐benzyl‐DL‐myo‐inositol and 1,2,3,4, 6‐penta‐O‐benzyl‐5‐0‐methyl‐^14^C‐myo‐inositol were cleaved by hydrogenolysis catalyzed by palladium on carbon‐palladium chloride (5 : 1) to obtain the 1‐O‐ and 5‐O‐methyl‐^14^C‐myo‐inositols respectively.

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