✍ Scribed by J. P. Noel; L. Pichat
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3-1 [ 2 , 6-14C] 2 -p y r i d i n y l d i t h i o ) propanoic a c i d , a d i s u l p h i J e 1 4 c o v a l e n t coupling reagent was s y n t h e s i z e d i n 1 2 s t e m
n i a . The imide : -5_ was t h e n converted i n t o 12.6-C] 2,6-dichloropyridine :
Was tranformed int,; [2,6-C ] pyridine-N-oxide :1_1. by hydrogen peroxide treatment. Lz. t r e a t e d by a c e t i c anhydride (15 hours -130°C) rearranged i n t o 2-acetyloxy 1-2, 6-14C] p y r i d i n e : 14 -* A d d r e s s any correspondence t o t h i s a u t h o r .
📜 SIMILAR VOLUMES
## Abstract The synthesis of ^14^C‐2,3 dimercapto sucinic acid (DMSA) is described. The starting material ^14^C‐2,3 succinic acid was brominated and then deshydrohalogenated to give acetylenedicarboxylic acid. This ^14^C‐acetylenic compound was transformed into ^14^C‐dithioacetylsuccinic acid. This
Epoxy ring opening of 2 and 2 with [ l -1 4 C ] hexadecyl copper lo gave respectivezy t h e analog 4 of agaric acid trimethyl e s t e r and methy2 b -1 4 ~J a g a r i c a t e 5, which-was hydrolysed t o -& by Zithium hy-&oxide i n I, 2-dimethoxyethane (DME). Epoxy ring trans opening of -2 with d i
The two compounds were labelled by ^14^C on the hydroxyimino methyl group substituted on the 2 positions of the pyridinium ring. The convenient pyridinium lithiated intermediates were formylated with N‐methyl ^14^C‐formanilide. The hydroxyimino methyl groups were synthezised by reaction of the ^14^
The ^14^C labelling of three compounds : HI‐6, TMB‐4 and pyrimidoxime is described from ^14^C‐formic acid, sodium salt. The compounds were prepared by lithiation and formylation with N‐methyl (^14^C)‐formanilide followed by introduction of the hydroxylamine moieties and alkylation of the pyridine. R