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Synthese De L'Acide Dimercapto-2,3 Succinique-14C-2,3

✍ Scribed by P.-L. Compagnon; Tan Kimny; J. R. Rapin

Publisher
John Wiley and Sons
Year
1980
Tongue
French
Weight
157 KB
Volume
17
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of ^14^C‐2,3 dimercapto sucinic acid (DMSA) is described. The starting material ^14^C‐2,3 succinic acid was brominated and then deshydrohalogenated to give acetylenedicarboxylic acid. This ^14^C‐acetylenic compound was transformed into ^14^C‐dithioacetylsuccinic acid. This latter compound was hydrolysed with sodium hydroxyde to give ^14^C‐DMSA. The overall yield was 57% at a specific activity of 1.6 mCi/mM.

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