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Synthese de L'Acide (Propyl-1-13C)-2 Pentanoique-3-13C (acide valproïque)

✍ Scribed by C. Servens; C. Filliatre; R. Sion

Publisher
John Wiley and Sons
Year
1985
Tongue
French
Weight
301 KB
Volume
22
Category
Article
ISSN
0022-2135

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✦ Synopsis

A method was developped f o r t h e s y n t h e s i s of 2 -( p r 0 p y l -l -~~C ) pentanoic-3-13C a c i d on a scale of t e n grams and with an i s o t o p i c p u r i t y of 98,9 %.

Grace B s e s p r o p r i e t e s anti-convulsivantes (l), l e sel de sodium de l ' a c i d e p r o p y l a pentanorque ( v s l p r o a t e de sodium -Depakine R, Laboratoires LABAZ) est un medicament largement u t i l i s e pour l e traitement de l ' e p i l e p s i e .

L'Btude de son mecanisme d ' a c t i o n a f a i t l ' o b j e t de p l u s i e u r s mises au p o i n t (2,3) e t n e c e s s i t e p a r f o i s l ' u t i l i s a t i o n de molecules marquees. L a synthkse de l ' a c i d e l4C en p o s i t i o n a a B t B d e c r i t e par V.V. RANADE et A. ALTER

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