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Synthese radioactive de sels d'ammonium quaternaires d'hydroxy imino methyl-2 OU -4 pyridinyle par l'intermediaire de la N-methyl formanilide-14C. II. Marquage par 14C de l'iodure d'[hydroxyimino methyl-2 methyl-1 pyridinyle ou 2-PAM Iodure et du diodure de trimethylène dioxy-3,3′ bis [hydroxy imino methyl-2 methyl-1, pyridinyle] ou R-665

✍ Scribed by J. C. Madelmont; C. Nicolas; J. C. Maurizis; J. M. Dupuy; H. Garrigue; J. M. Meyniel; P. Demerseman; H. Sentenac-Roumanou; Et A. Veyre

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
306 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis

The two compounds were labelled by ^14^C on the hydroxyimino methyl group substituted on the 2 positions of the pyridinium ring.

The convenient pyridinium lithiated intermediates were formylated with N‐methyl ^14^C‐formanilide. The hydroxyimino methyl groups were synthezised by reaction of the ^14^C‐formyl compound with hydroxylamine. For the two species alkylation of pyridine was performed with methyliodide. Radiochemical yields were 50% and 20%.

📜 SIMILAR VOLUMES

Synthese radioactive de sels d'ammonium
Synthese radioactive de sels d'ammonium quaternaires d'hydroxy imino methyl-2 OU-4 pyridinium au moyen de la N-methyl formanilide-14C. I - marquage du dichlorure d'(hydroxyimino méthyl (14c)-2 pyridinyle)-1 (aminocarbonyl-4′ pyridinyle)-1′ dimethyl éther ou hi-6-(14c); du dibromure de bis [hydroxyimino méthyl (14c)-4 pyridinyle]-1,3 propane ou tmb-4-(14c) et du dibromure d'(hydroxyimino méthyl (14c)-4 pyridinyle)-1 (méthyl-3′ imidazolyle)-3 propane ou pyrimidoxime-(14C)
✍ C. Nicolas; J. C. Madelmont; J. C. Maurizis; H. Garrigue; J. M. Meyniel; P. Deme 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 357 KB

The ^14^C labelling of three compounds : HI‐6, TMB‐4 and pyrimidoxime is described from ^14^C‐formic acid, sodium salt. The compounds were prepared by lithiation and formylation with N‐methyl (^14^C)‐formanilide followed by introduction of the hydroxylamine moieties and alkylation of the pyridine. R