𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthese de l'acide nervonique 14C-24 (acide cis-tétracosène-15 oïque 14C-24)

✍ Scribed by T. Moriya; M. Pabiot; L. Pichat

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
348 KB
Volume
18
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Methyl iodide‐^14^C was condensed with 2‐(1‐lithio‐hept‐1‐yn‐6‐yl) 1,3‐dioxolanne 4 in presence of HMPT and benzene to give 2‐(oct‐2‐yn‐8‐yl‐1‐^14^C) 1,3‐dioxolanne 5.

Catalytic reduction of 5, followed by acid hydrolysis led to pelargonic aldehyde 9‐^14^C 7. Condensation of this aldehyde 7 with an excess of w‐carbomethoxy‐tetradecylidene), triphenyl phosphorane 11 produced methyl nervonate 24‐ ^14^C 12. The latter was isolated from its trans isomer by chromatography on a silver nitrate impregnated silicagel column. Finally, nervonic acid 24‐^14^C 13 was obtained by alkaline hydrolysis (specific activity : 52 mCi/mMole) with an overall yield of 7% based on methyl iodide‐^14^C.

📜 SIMILAR VOLUMES

Synthese De L'Acide Dimercapto-2,3 Succi
Synthese De L'Acide Dimercapto-2,3 Succinique-14C-2,3
✍ P.-L. Compagnon; Tan Kimny; J. R. Rapin 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 French ⚖ 157 KB

## Abstract The synthesis of ^14^C‐2,3 dimercapto sucinic acid (DMSA) is described. The starting material ^14^C‐2,3 succinic acid was brominated and then deshydrohalogenated to give acetylenedicarboxylic acid. This ^14^C‐acetylenic compound was transformed into ^14^C‐dithioacetylsuccinic acid. This

Synthese De La Beta-naphtoflavone 14C-4
Synthese De La Beta-naphtoflavone 14C-4 OU 14C-5 A Partir De L'Acide Phenylpropiolique (CARBOXYLE14C) Ou Du β-Naphtol 14C-8
✍ Nguyen-Hoang Nam; Do-Cao Thang; P. Queval; L. Pichat 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 French ⚖ 235 KB

## Abstract Carbonation with ^14^CO~2~ of penylethynyl‐lithium has given rise to (carboxyl‐^14^C) phenylpropiolic acid with 75 % yield based on ^14^CO^2^. The latter condensed with 2‐naphthol by treating with polyphosphoric acid afforded (4‐^14^C) β‐naphthoflavone, purified by silicagel low pressur

Synthese de l'acide acetoxy-2 trifluorom
Synthese de l'acide acetoxy-2 trifluoromethyl-4 benzoique [noyau 14C-U] OU “triflusal [noyau 14C-U]”
✍ J. P. Noel; L. Pichat; V. Rimbau; J. Forn 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 French ⚖ 357 KB

S y n t h e s i s o f a c e t o x y 4 -t r i f l y t r o m e t h y l b e n z o i c a c i d [ r i n g U-i ' C] o r " [ r i n g U -C] T r i f u s a l " ( R i n g U-14C) A n i l i n e 1 was c o n v e r t e i n t o ( r i n g U -1 4 C ) i d o b e n z e n e 2 t h r o u g h t h e ( r i n g U -f 4 C ) p h e

Substances naturelles marquees au cardop
Substances naturelles marquees au cardopn14: Synthese de l'acide withranilioue (carboxylc 14C), precurseur bio-sehtioe de l'ellipticine
✍ Nguyen Van Bac; Michel Herbert; Louis Pichat; Nguyen Dat-Xuong 📂 Article 📅 1973 🏛 John Wiley and Sons 🌐 French ⚖ 245 KB

## Abstract La carbonisation du lithien du bromo‐2 acétanilide ne donne qu'sun faible rendement en acide anthranilique. La carbonisation du promure d'o‐chlorphénylmaanésium pur ^14^CO~2~ conduit à l'acide o‐chlorobenzoique ( carboxyle ^14^c ) dont l'a‐mination deshalogénante fournit l'acide anthra

Synthese de L'Acide [Pyridinyl-2-(14C-2,
Synthese de L'Acide [Pyridinyl-2-(14C-2,6) Dithio]-3 Propanoique Reactif de Couplage Covalent
✍ J. P. Noel; L. Pichat 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 French ⚖ 499 KB

3-1 [ 2 , 6-14C] 2 -p y r i d i n y l d i t h i o ) propanoic a c i d , a d i s u l p h i J e 1 4 c o v a l e n t coupling reagent was s y n t h e s i z e d i n 1 2 s t e m ## a f t e r h y d r o l y s i s [1,5- i n t o [1,5-C l g l u t a r i m i d e : -5_ by h e a t i n g a t 280°C w i t h anhydro